第一单位：
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
作者：
André,Richters [1]
;
Shelby K,Doyle [2]
;
David B,Freeman [3]
;
Christina,Lee [3]
;
Becky S,Leifer [1]
;
Sajjeev,Jagannathan [4]
;
Florian,Kabinger [1]
;
Jošt Vrabič,Koren [4]
;
Nicholas B,Struntz [1]
;
Julie,Urgiles [5]
;
Ryan A,Stagg [6]
;
Brice H,Curtin [1]
;
Deep,Chatterjee [7]
;
Sebastian,Mathea [7]
;
Peter J,Mikochik [3]
;
Tamara D,Hopkins [3]
;
Hua,Gao [3]
;
Jonathan R,Branch [8]
;
Hong,Xin [8]
;
Lori,Westover [8]
;
Gilles C,Bignan [8]
;
Brent A,Rupnow [8]
;
Kristen L,Karlin [4]
;
Calla M,Olson [4]
;
Thomas F,Westbrook [4]
;
Joseph,Vacca [3]
;
Chris M,Wilfong [3]
;
B Wesley,Trotter [3]
;
Douglas C,Saffran [3]
;
Norbert,Bischofberger [3]
;
Stefan,Knapp [7]
;
Joshua W,Russo [9]
;
Ian,Hickson [10]
;
James R,Bischoff [8]
;
Marco M,Gottardis [8]
;
Steven P,Balk [9]
;
Charles Y,Lin [11]
;
Marius S,Pop [3]
;
Angela N,Koehler [12]
作者单位：
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
[1]
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
[2]
Kronos Bio, Inc., Cambridge, MA 02139, USA.
[3]
Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
[4]
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Harvard-MIT Health Sciences and Technology, Boston, MA 02115, USA.
[5]
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Boston University, Boston, MA 02215, USA.
[6]
Goethe-Universität Frankfurt, 60438 Frankfurt am Main, Germany.
[7]
Janssen Research & Development, LLC, Spring House, PA, USA.
[8]
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
[9]
Janssen Research & Development, LLC, Spring House, PA, USA; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
[10]
Kronos Bio, Inc., Cambridge, MA 02139, USA; Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
[11]
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: koehler@mit.edu.
[12]
医学主题词
雄激素受体拮抗剂(Androgen Receptor Antagonists);动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);细胞周期蛋白依赖激酶9(Cyclin-Dependent Kinase 9);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);模型, 分子(Models, Molecular);蛋白激酶抑制剂(Protein Kinase Inhibitors);受体, 雄激素(Receptors, Androgen);转录, 遗传(Transcription, Genetic)
DOI
10.1016/j.chembiol.2020.10.001
PMID
33086052
发布时间
2026-03-23
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