DNA Methylation at Birth Predicts Intellectual Functioning and Autism Features in Children with Fragile X Syndrome.

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作者： Claudine M,Kraan ^[1] ; Emma K,Baker ^[2] ; Marta,Arpone ^[1] ; Minh,Bui ^[2] ; Ling,Ling ^[3] ; Dinusha,Gamage ^[1] ; Lesley,Bretherton ^[2] ; Carolyn,Rogers ^[4] ; Michael J,Field ^[5] ; Tiffany L,Wotton ^[1] ; David,Francis ^[1] ; Matt F,Hunter ^[1] ; Jonathan,Cohen ^[6] ; David J,Amor ^[6] ; David E,Godler ^[7]

作者单位： Diagnosis and Development, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, VIC 3052, Australia. ^[1] Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3052, Australia. ^[2] School of Psychology and Public Health, La Trobe University, Bundoora, VIC 3086, Australia. ^[3] Brain and Mind, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC 3052, Australia. ^[4] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne VIC 3052, Australia. ^[5] Genetics of Learning Disability Service (GOLD service), Hunter Genetics, Newcastle, NSW 2298, Australia. ^[6] New South Wales Newborn Screening Program, Children's Hospital at Westmead, Sydney, NSW 2145, Australia. ^[7] Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, VIC 3052, Australia. ^[8] Monash Genetics, Monash Health, Clayton, VIC 3168, Australia. ^[9] Centre for Developmental Disability Health Victoria, Monash University, Doveton VIC 3177, Australia. ^[10] Fragile X Alliance Inc., North Caulfield, VIC 3161, Australia. ^[11]

关键词 DNA methylation (DNAm)autism spectrum disorder (ASD)fragile X mental retardation 1 gene (FMR1 gene)fragile X syndrome (FXS)intellectual disability (ID)newborn screening