首页> The Journal of biological chemistry> The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2.

The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2.

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第一作者： Nilüfer N,Turan

第一单位： Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.

作者： Nilüfer N,Turan ^[1] ; Karni S,Moshal ^[1] ; Karim,Roder ^[1] ; Brett C,Baggett ^[1] ; Anatoli Y,Kabakov ^[1] ; Saroj,Dhakal ^[2] ; Ryota,Teramoto ^[3] ; David Yi-Eng,Chiang ^[3] ; Mingwang,Zhong ^[2] ; An,Xie ^[4] ; Yichun,Lu ^[1] ; Samuel C,Dudley ^[4] ; Calum A,MacRae ^[3] ; Alain,Karma ^[2] ; Gideon,Koren ^[5]

作者单位： Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA. ^[1] Physics Department and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts, USA. ^[2] Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ^[3] Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA. ^[4] Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA. Electronic address: gideon_koren@brown.edu. ^[5]

关键词 E3 ubiquitin ligase LITAF NEDD4-2 Nav1.5 action potential duration cardiomyocyte computer modelling sodium channel ubiquitin zebrafish