Targeting N-myristoylation for therapy of B-cell lymphomas.-论文-万方医学网

第一作者： Erwan,Beauchamp

第一单位： Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, T6G 2H7, AB, Canada.

作者： Erwan,Beauchamp ^[1] ; Megan C,Yap ^[2] ; Aishwarya,Iyer ^[1] ; Maneka A,Perinpanayagam ^[2] ; Jay M,Gamma ^[1] ; Krista M,Vincent ^[1] ; Manikandan,Lakshmanan ^[2] ; Anandhkumar,Raju ^[3] ; Vinay,Tergaonkar ^[4] ; Soo Yong,Tan ^[5] ; Soon Thye,Lim ^[6] ; Wei-Feng,Dong ^[7] ; Lynne M,Postovit ^[6] ; Kevin D,Read ^[7] ; David W,Gray ^[6] ; Paul G,Wyatt ^[7] ; John R,Mackey ^[8] ; Luc G,Berthiaume ^[4]

作者单位： Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, T6G 2H7, AB, Canada. ^[1] Pacylex Pharmaceuticals Inc., Edmonton, AB, Canada. ^[2] Departments of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, T6G 2H7, AB, Canada. ^[3] Departments of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, T6G 2H7, AB, Canada. ^[4] Mouse Models of Human Cancer Unit, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673, Singapore. ^[5] Advanced Molecular Pathology Lab, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore, 138673. ^[6] Department of Pathology, National University of Singapore, Singapore, Singapore. ^[7] Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Outram Road, Singapore, 169610, Singapore. ^[8] Drug Discovery Unit, School of Life Sciences, University of Dundee, James Black Centre, Dow Street, Dundee, DD1 5EH, UK. ^[9] Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, T6G 2H7, AB, Canada. luc.berthiaume@ualberta.ca. ^[10] Pacylex Pharmaceuticals Inc., Edmonton, AB, Canada. luc.berthiaume@ualberta.ca. ^[11]

主题词酰基转移酶类(Acyltransferases);腺嘌呤(Adenine);氨基吡啶类(Aminopyridines);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);人类(Humans);淋巴瘤, B细胞(Lymphoma, B-Cell);小鼠(Mice);小鼠, SCID(Mice, SCID);模型, 生物学(Models, Biological);肉豆蔻酸(Myristic Acid);哌啶类(Piperidines);吡唑类(Pyrazoles);嘧啶类(Pyrimidines);受体, 抗原, B细胞(Receptors, Antigen, B-Cell);信号传导(Signal Transduction);磺胺类(Sulfonamides);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);src族激酶类(src-Family Kinases)

DOI 10.1038/s41467-020-18998-1

PMID 33093447

发布时间 2021-12-04

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Targeting N-myristoylation for therapy of B-cell lymphomas.

Nature communications

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Targeting N-myristoylation for therapy of B-cell lymphomas.

Nature communications

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Nature communications

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