TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer.-论文-万方医学网

作者： Shan,Zhang ^[1] ; Peiqi,Huang ^[2] ; Huijuan,Dai ^[1] ; Qing,Li ^[2] ; Lipeng,Hu ^[2] ; Jing,Peng ^[1] ; Shuheng,Jiang ^[2] ; Yaqian,Xu ^[1] ; Ziping,Wu ^[1] ; Huizhen,Nie ^[2] ; Zhigang,Zhang ^[2] ; Wenjin,Yin ^[3] ; Xueli,Zhang ^[4] ; Jinsong,Lu ^[5]

作者单位： Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 1630 Dongfang Road, Shanghai, 200127, China. ^[1] State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200240, China. ^[2] Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 1630 Dongfang Road, Shanghai, 200127, China. followroad@163.com. ^[3] State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200240, China. xlzhang@shsci.org. ^[4] Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 1630 Dongfang Road, Shanghai, 200127, China. lujjss@163.com. ^[5]

主题词碱性神经酰胺酶(Alkaline Ceramidase);动物(Animals);活组织检查(Biopsy);乳腺肿瘤(Breast Neoplasms);细胞周期蛋白质类(Cell Cycle Proteins);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因敲低技术(Gene Knockdown Techniques);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);溶血磷脂素类(Lysophospholipids);小鼠(Mice);小鼠, 裸(Mice, Nude);线粒体(Mitochondria);Sp1转录因子(Sp1 Transcription Factor);鞘脂类(Sphingolipids);鞘氨醇(Sphingosine);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1038/s41419-020-03106-4

PMID 33093451

发布时间 2023-12-13

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TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer.

Cell death & disease

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TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer.

Cell death & disease

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Cell death & disease

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