换一批Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1β/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model.
第一作者：
Ailing,Sui
第一单位：
The Department of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
作者：
医学主题词
血管生成素类(Angiopoietins);动物(Animals);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);疾病模型, 动物(Disease Models, Animal);内皮细胞(Endothelial Cells);呋喃类(Furans);基因表达调控, 发育期(Gene Expression Regulation, Developmental);人类(Humans);茚类(Indenes);炎性体(Inflammasomes);白细胞介素18(Interleukin-18);白细胞介素1β(Interleukin-1beta);缺血(Ischemia);基质金属蛋白酶类(Matrix Metalloproteinases);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);氧(Oxygen);受体, 血小板源生长因子(Receptors, Platelet-Derived Growth Factor);受体, 血管内皮生长因子(Receptors, Vascular Endothelial Growth Factor);重组蛋白质类(Recombinant Proteins);视网膜疾病(Retinal Diseases);视网膜新生血管化(Retinal Neovascularization);视网膜血管(Retinal Vessels);磺胺类(Sulfonamides);砜类(Sulfones);血管内皮生长因子A(Vascular Endothelial Growth Factor A)
DOI
10.1038/s41419-020-03076-7
PMID
33093455
发布时间
2021-12-14
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