Preparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties.

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作者： Brice,Martin ^[1] ; Johanne,Seguin ^[2] ; Maxime,Annereau ^[1] ; Thomas,Fleury ^[3] ; René,Lai-Kuen ^[3] ; Giovanni,Neri ^[4] ; Anita,Lam ^[1] ; Marcel,Bally ^[5] ; Nathalie,Mignet ^[6] ; Yohann,Corvis ^[1]

作者单位： Université de Paris, CNRS, Inserm, UTCBS, Chemical and Biological Technologies for Health Group (utcbs.cnrs.fr), Faculté de Pharmacie, 4 Avenue de l'Observatoire, 75006, Paris, France. ^[1] Department of Neurological Surgery, Weill Medical College of Cornell University, New York, NY, USA. ^[2] Gustave Roussy, 114 rue Edouard Vaillant, 94800, PharmacyVillejuif, France. ^[3] Université de Paris, CNRS, Inserm, Cellular and Molecular Imaging Technology Platform, Faculté de Pharmacie, 4 Avenue de l'Observatoire, 75006, Paris, France. ^[4] Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T 1Z1, Canada. ^[5] Department of Experimental Therapeutics, British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada. ^[6] Université de Paris, CNRS, Inserm, UTCBS, Chemical and Biological Technologies for Health Group (utcbs.cnrs.fr), Faculté de Pharmacie, 4 Avenue de l'Observatoire, 75006, Paris, France. yohann.corvis@u-paris.fr. ^[7]