Recent advances in the design of choline kinase α inhibitors and the molecular basis of their inhibition.

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第一作者： Belén,Rubio-Ruiz

第一单位： Department of Medicinal and Organic Chemistry, Faculty of Pharmacy, University of Granada, Granada, Spain.;Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.;Biosanitary Institute of Granada (ibs.GRANADA), SAS-University of Granada, Granada, Spain.

作者： Belén,Rubio-Ruiz ^[1] ; Lucía,Serrán-Aguilera ^[2] ; Ramón,Hurtado-Guerrero ^[3] ; Ana,Conejo-García ^[4]

作者单位： Department of Medicinal and Organic Chemistry, Faculty of Pharmacy, University of Granada, Granada, Spain.;Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Granada, Spain.;Biosanitary Institute of Granada (ibs.GRANADA), SAS-University of Granada, Granada, Spain. ^[1] Department of Medicinal and Organic Chemistry, Faculty of Pharmacy, University of Granada, Granada, Spain. ^[2] Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Zaragoza, Spain.;Department of Cellular and Molecular Medicine, Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen, Denmark.;Laboratorio de Microscopías Avanzada, University of Zaragoza, Zaragoza, Spain.;ARAID Foundation, Zaragoza, Spain. ^[3] Department of Medicinal and Organic Chemistry, Faculty of Pharmacy, University of Granada, Granada, Spain.;Biosanitary Institute of Granada (ibs.GRANADA), SAS-University of Granada, Granada, Spain. ^[4]

关键词 cancer choline kinase inhibitors malaria structure-based drug design

主题词结合部位(Binding Sites);细胞转化, 肿瘤(Cell Transformation, Neoplastic);胆碱激酶(Choline Kinase);酶抑制剂(Enzyme Inhibitors);人类(Humans)

DOI 10.1002/med.21746

PMID 33103259

发布时间 2021-10-28

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