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Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility.

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第一作者: Rushika C,Wirasinha
第一单位: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
作者单位: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia. [1] Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia.;Translational Research Unit, Department of Immunology, The Canberra Hospital, Canberra, Australia.;Centre for Personalised Immunology (NHMRC Centre of Research Excellence), John Curtin School of Medical Research, Australian National University, Canberra, Australia. [2] Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia. [3] Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.;Department of Medical Biology, University of Melbourne, Melbourne, Australia. [4] Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. [5] Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia.;Translational Research Unit, Department of Immunology, The Canberra Hospital, Canberra, Australia. [6] Division of Allergy and Immunology, Children's National Medical Center, Washington, DC. [7] Department of Pediatrics, University of Utah, Salt Lake City, UT.;Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA. [8] Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.;Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Australia.;Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK. [9] Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia.;Centre for Personalised Immunology (NHMRC Centre of Research Excellence), John Curtin School of Medical Research, Australian National University, Canberra, Australia. [10] Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.;Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Australia. [11] Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. [12] Garvan Institute of Medical Research & Cellular Genomics Futures Institute, University of New South Wales, Sydney, Australia. [13]
DOI 10.1084/jem.20200476
PMID 33107914
发布时间 2021-09-09
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The Journal of experimental medicine

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