A Respiratory Syncytial Virus Attachment Gene Variant Associated with More Severe Disease in Infants Decreases Fusion Protein Expression, Which May Facilitate Immune Evasion.

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作者： Stacey,Human ^[1] ; Anne L,Hotard ^[2] ; Christina A,Rostad ^[1] ; Sujin,Lee ^[2] ; Louise,McCormick ^[1] ; Emma K,Larkin ^[2] ; Teresa C T,Peret ^[1] ; Jaume,Jorba ^[2] ; Joseph,Lanzone ^[1] ; Tebeb,Gebretsadik ^[2] ; John V,Williams ^[3] ; Melissa,Bloodworth ^[4] ; Matthew,Stier ^[5] ; Kecia,Carroll ^[6] ; R Stokes,Peebles ^[1] ; Larry J,Anderson ^[2] ; Tina V,Hartert ^[7] ; Martin L,Moore ^[8]

作者单位： Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA. ^[1] Children's Healthcare of Atlanta, Atlanta, Georgia, USA. ^[2] Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. ^[3] Center for Asthma Research, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. ^[4] Respiratory Viruses Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. ^[5] Viral Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. ^[6] Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. ^[7] University of Pittsburgh, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. ^[8] Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. ^[9] Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA tina.hartert@vumc.org martin.moore@meissavaccines.com. ^[10] Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA tina.hartert@vumc.org martin.moore@meissavaccines.com. ^[11]

关键词 A4G G glycoprotein disease severity gene end gene variant infant respiratory syncytial virus tandem stop codons transcriptional regulation wheeze