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Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models.

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第一作者： Suraj U,Hettiarachchi

第一单位： Department of Chemistry and Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.

作者： Suraj U,Hettiarachchi ^[1] ; Yen-Hsing,Li ^[1] ; Jyoti,Roy ^[1] ; Fenghua,Zhang ^[1] ; Estela,Puchulu-Campanella ^[1] ; Spencer D,Lindeman ^[1] ; Madduri,Srinivasarao ^[1] ; Konstantin,Tsoyi ^[2] ; Xiaoliang,Liang ^[2] ; Ehab A,Ayaub ^[3] ; Cheryl,Nickerson-Nutter ^[4] ; Ivan O,Rosas ^[2] ; Philip S,Low ^[5]

作者单位： Department of Chemistry and Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA. ^[1] Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.;Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA. ^[2] Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ^[3] Three Lakes Foundation, Northbrook, IL 60062, USA. ^[4] Department of Chemistry and Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA. plow@purdue.edu. ^[5]