Directed Evolution of the Nonribosomal Peptide Synthetase BpsA to Enable Recognition by the Human Phosphopantetheinyl Transferase for Counter-Screening Antibiotic Candidates.

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作者： Alistair S,Brown ^[1] ; Jack A,Sissons ^[2] ; Jeremy G,Owen ^[3] ; David F,Ackerley ^[1]

作者单位： School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand. ^[1] Centre for Biodiscovery, School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand. ^[2] Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand. ^[3]

关键词 4′-phosphopantetheinyl transferase NRPS Type II PPTase aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase antibiotic screening indigoidine

主题词动物(Animals);抗菌药(Anti-Bacterial Agents);细菌蛋白质类(Bacterial Proteins);人类(Humans);肽合酶类(Peptide Synthases);大鼠(Rats);转移酶类(其他取代磷酸族)(Transferases (Other Substituted Phosphate Groups))

DOI 10.1021/acsinfecdis.0c00606

PMID 33118808

发布时间 2021-06-23

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ACS infectious diseases

2020年6卷11期

2879-2886页

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Directed Evolution of the Nonribosomal Peptide Synthetase BpsA to Enable Recognition by the Human Phosphopantetheinyl Transferase for Counter-Screening Antibiotic Candidates.

ACS infectious diseases

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ACS infectious diseases

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Directed Evolution of the Nonribosomal Peptide Synthetase BpsA to Enable Recognition by the Human Phosphopantetheinyl Transferase for Counter-Screening Antibiotic Candidates.

ACS infectious diseases

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ACS infectious diseases

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