The Oncometabolite 5'-Deoxy-5'-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation.
第一作者:
Benedikt,Jacobs
第一单位:
Department of Internal Medicine 5, Hematology and Oncology, Friedrich Alexander University Erlangen-Nuremberg (FAU), University Hospital Erlangen, Erlangen, Germany.
作者:
医学主题词
细胞脱颗粒(Cell Degranulation);细胞, 培养的(Cells, Cultured);细胞因子类(Cytokines);细胞毒性, 免疫(Cytotoxicity, Immunologic);脱氧腺苷类(Deoxyadenosines);GPI连接蛋白质类(GPI-Linked Proteins);人类(Humans);干扰素γ(Interferon-gamma);K562细胞(K562 Cells);杀伤细胞, 天然(Killer Cells, Natural);淋巴细胞亚群(Lymphocyte Subsets);溶酶体相关膜蛋白质1(Lysosomal-Associated Membrane Protein 1);NF-κB(NF-kappa B);NK细胞凝集素样受体亚家族C(NK Cell Lectin-Like Receptor Subfamily C);蛋白质精氨酸N-甲基转移酶(Protein-Arginine N-Methyltransferases);嘌呤核苷磷酸化酶(Purine-Nucleoside Phosphorylase);受体, IgG(Receptors, IgG);信号传导(Signal Transduction);硫代核苷类(Thionucleosides);肿瘤逃逸(Tumor Escape);肿瘤干细胞测定(Tumor Stem Cell Assay)
DOI
10.3389/fimmu.2020.02128
PMID
33123121
发布时间
2021-12-04
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