Cardiac Imaging of Aortic Valve Area From 34 287 UK Biobank Participants Reveals Novel Genetic Associations and Shared Genetic Comorbidity With Multiple Disease Phenotypes.

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第一作者： Aldo,Córdova-Palomera

第一单位： Department of Pediatrics, Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA (A.C.-P., C.T., K.X., H.T., J.R.P.).

作者： Aldo,Córdova-Palomera ^[1] ; Catherine,Tcheandjieu ^[1] ; Jason A,Fries ^[2] ; Paroma,Varma ^[3] ; Vincent S,Chen ^[4] ; Madalina,Fiterau ^[2] ; Ke,Xiao ^[2] ; Heliodoro,Tejeda ^[1] ; Bernard D,Keavney ^[1] ; Heather J,Cordell ^[5] ; Yosuke,Tanigawa ^[6] ; Guhan,Venkataraman ^[7] ; Manuel A,Rivas ^[8] ; Christopher,Ré ^[8] ; Euan,Ashley ^[8] ; James R,Priest ^[2]

作者单位： Department of Pediatrics, Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA (A.C.-P., C.T., K.X., H.T., J.R.P.). ^[1] Department of Computer Science (J.F., V.S.C., M.F., C.R.), Stanford University, CA. ^[2] Center for Biomedical Informatics Research (J.F.), Stanford University, CA. ^[3] Department of Electrical Engineering (P.V.), Stanford University, CA. ^[4] Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom (B.K.). ^[5] Division of Medicine, Manchester University National Health Service Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom (B.K.). ^[6] Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom (H.J.C.). ^[7] Department of Biomedical Data Science (Y.T., G.V., M.R.), Stanford University, CA. ^[8] Department of Medicine (E.A.), Stanford University, CA. ^[9] Chan Zuckerberg Biohub, San Francisco, CA (E.A., J.R.P.). ^[10]

关键词 aortic valve birth weight humans molecular epidemiology odds ratio

主题词成年人(Adult);老年人(Aged);主动脉瓣(Aortic Valve);主动脉瓣狭窄(Aortic Valve Stenosis);生物标本库(Biological Specimen Banks);心血管疾病(Cardiovascular Diseases);共病现象(Comorbidity);女(雌)性(Female);基因组, 人(Genome, Human);全基因组关联研究(Genome-Wide Association Study);人类(Humans);磁共振成像(Magnetic Resonance Imaging);男(雄)性(Male);中年人(Middle Aged);多因子遗传(Multifactorial Inheritance);表型(Phenotype);存活率分析(Survival Analysis)

DOI 10.1161/CIRCGEN.120.003014

PMID 33125279

发布时间 2022-02-16

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Circulation. Genomic and precision medicine

2020年13卷6期

e003014页

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Cardiac Imaging of Aortic Valve Area From 34 287 UK Biobank Participants Reveals Novel Genetic Associations and Shared Genetic Comorbidity With Multiple Disease Phenotypes.

Circulation. Genomic and precision medicine

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Cardiac Imaging of Aortic Valve Area From 34 287 UK Biobank Participants Reveals Novel Genetic Associations and Shared Genetic Comorbidity With Multiple Disease Phenotypes.

Circulation. Genomic and precision medicine

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Circulation. Genomic and precision medicine

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