换一批Inhibition of long noncoding RNA HIF1A-AS2 confers protection against atherosclerosis <i>via</i> ATF2 downregulation.
第一作者：
Pengcheng,Li
第一单位：
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, PR China.
作者：
关键词
ATCC, American Type Culture CollectionATF2, activating transcription factor 2Activating transcription factorAtherosclerosisCAD, coronary artery diseaseCCK-8, cell counting kit-8ChIP, Chromatin immunoprecipitationDMEM, Dulbecco’s modified Eagle’s mediumECs, endothelial cellsELISA, enzyme linked immunosorbent assayGAPDH, Glyceraldehyde-3-phosphate dehydrogenaseHCAECs, human coronary artery endothelial cellsHE, Hematoxylin-eosinHFD, high fat dietHIF1A-AS2, hypoxia-inducible factor 1 alpha-antisense RNA 2Hypoxia-inducible factor 1 alpha-antisense RNA 2ICAM-1, intercellular adhesion molecule-1IL-1β, interleukin-1βIL-6, interleukin-6IgG, immunoglobulin GInflammationLDL, low-density lipoproteinLong noncoding RNAMCP-1, monocyte chemoattractant protein-1ND, normal dietPBS, phosphate buffered salineRIP, RNA binding protein immunoprecipitationRT-qPCR, reverse transcription quantitative polymerase chain reactionSMCs, smooth muscle cellsTNF-α, tumor necrosis factor-αTranscription factorUSF1, upstream stimulatory factor 1Upstream transcription factor 1VCAM-1, vascular cell adhesion molecule 1lncRNAs, long noncoding RNAsox-LDL, oxidized-low-density lipoproteinsh, short hairpin RNAsi-NC, small interfering RNA-negative control
DOI
10.1016/j.jare.2020.07.015
PMID
33133688
发布时间
2022-04-18
- 浏览4
Journal of advanced research
2020年26卷
123-135页
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