首页> Proceedings of the National Academy of Sciences of the United States of America> A missense variant in <i>SLC39A8</i> confers risk for Crohn's disease by disrupting manganese homeostasis and intestinal barrier integrity.

A missense variant in <i>SLC39A8</i> confers risk for Crohn's disease by disrupting manganese homeostasis and intestinal barrier integrity.

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第一作者： Toru,Nakata

第一单位： Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142.;Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.;Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02215.

作者： Toru,Nakata ^[1] ; Elizabeth A,Creasey ^[1] ; Motohiko,Kadoki ^[1] ; Helen,Lin ^[1] ; Martin K,Selig ^[2] ; Junmei,Yao ^[1] ; Ariel,Lefkovith ^[3] ; Mark J,Daly ^[4] ; Daniel B,Graham ^[5] ; Ramnik J,Xavier ^[5]

作者单位： Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142.;Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.;Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02215. ^[1] Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114. ^[2] Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142. ^[3] Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142.;Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114. ^[4] Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142; dgraham@broadinstitute.org xavier@molbio.mgh.harvard.edu.;Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.;Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02215. ^[5]

关键词 Crohn’s disease barrier function glycocalyx inflammatory bowel disease manganese