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Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.

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第一作者： Yunxiao,Zhang

第一单位： Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.

作者： Yunxiao,Zhang ^[1] ; Wan-Jin,Lu ^[1] ; David P,Bulkley ^[2] ; Jiahao,Liang ^[3] ; Arthur,Ralko ^[4] ; Shuo,Han ^[1] ; Kelsey J,Roberts ^[5] ; Anping,Li ^[1] ; Wonhwa,Cho ^[4] ; Yifan,Cheng ^[6] ; Aashish,Manglik ^[7] ; Philip A,Beachy ^[8]

作者单位： Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305. ^[1] Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158. ^[2] Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158. ^[3] Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607. ^[4] Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305. ^[5] Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.;Howard Hughes Medical Institute, University of California, San Francisco, CA 94158. ^[6] Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158; aashish.manglik@ucsf.edu pbeachy@stanford.edu.;Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94158. ^[7] Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305; aashish.manglik@ucsf.edu pbeachy@stanford.edu.;Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.;Department of Urology, Stanford University School of Medicine, Stanford, CA 94305.;Department of Chemical and Systems Biology (by courtesy), Stanford University School of Medicine, Stanford, CA 94305. ^[8]

关键词 Patched cryo-EM hedgehog nanobody transporter

医学主题词动物(Animals);冷冻电子显微镜检查(Cryoelectron Microscopy);猬蛋白质类(Hedgehog Proteins);人类(Humans);信号传导(Signal Transduction)

DOI 10.1073/pnas.2011560117

PMID 33139559

发布时间 2021-05-02

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