Design, synthesis and evaluation of antiproliferative and antitubulin activities of 5-methyl-4-aryl-3-(4-arylpiperazine-1-carbonyl)-4H-1,2,4-triazoles.

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第一作者： Chao,Wang

第一单位： Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.

作者： Chao,Wang ^[1] ; Yuelin,Li ^[1] ; Tong,Liu ^[2] ; Zeyu,Wang ^[3] ; Yujing,Zhang ^[1] ; Kai,Bao ^[3] ; Yingliang,Wu ^[2] ; Qi,Guan ^[4] ; Daiying,Zuo ^[5] ; Weige,Zhang ^[6]

作者单位： Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. ^[1] Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. ^[2] Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. ^[3] Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: guanqi@syphu.edu.cn. ^[4] Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: zuodaiying@163.com. ^[5] Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: zhangweige2000@sina.com. ^[6]

关键词 1,2,4-triazole Antiproliferative activity Colchicine binding site inhibitor Molecular docking