Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.

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第一作者： Zheng-Zhao,Liu

第一单位： Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.

作者： Zheng-Zhao,Liu ^[1] ; Chun-Gu,Hong ^[2] ; Wen-Bao,Hu ^[3] ; Meng-Lu,Chen ^[4] ; Ran,Duan ^[5] ; Hong-Ming,Li ^[2] ; Tao,Yue ^[5] ; Jia,Cao ^[5] ; Zhen-Xing,Wang ^[6] ; Chun-Yuan,Chen ^[2] ; Xiong-Ke,Hu ^[3] ; Ben,Wu ^[2] ; Hao-Ming,Liu ^[3] ; Yi-Juan,Tan ^[1] ; Jiang-Hua,Liu ^[2] ; Zhong-Wei,Luo ^[1] ; Yan,Zhang ^[2] ; Shan-Shan,Rao ^[2] ; Ming-Jie,Luo ^[2] ; Hao,Yin ^[1] ; Yi-Yi,Wang ^[2] ; Kun,Xia ^[2] ; Lang,Xu ^[2] ; Si-Yuan,Tang ^[2] ; Rong-Gui,Hu ^[2] ; Hui,Xie ^[1]

作者单位： Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China. ^[1] Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China. ^[2] Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China. ^[3] Hunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Xiangya Hospital, Changsha, Hunan 410008, China. ^[4] Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China. ^[5] Hunan Key Laboratory of Bone Joint Degeneration and Injury, Xiangya Hospital, Changsha, Hunan 410008, China. ^[6] Xiangya Nursing School, Central South University, Changsha, Hunan, China. ^[7] State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network; Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Shanghai 200031, China. ^[8] Institue of Molecular Precision Medicine, Xiangya Hospital, Changsha, Hunan 410008, China. ^[9] National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China. ^[10]

关键词 Adipogenesis autophagy bone metabolism fabp3 mesenchymal stem cell optineurin osteogenesis osteoporosis senescence