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Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS.

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第一作者： Gianfranco Umberto,Meduri

第一单位： Memphis Veterans Affairs Medical Center Research Service, Departments of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA. gmeduri@uthsc.edu.;Pulmonary, Critical Care, and Sleep Medicine Service and Research Service, Memphis Veterans Affairs Medical Center, 1030 Jefferson Avenue, Suite room #CW444, Memphis, TN, 38104, USA. gmeduri@uthsc.edu.

作者： Gianfranco Umberto,Meduri ^[1] ; Djillali,Annane ^[2] ; Marco,Confalonieri ^[3] ; George P,Chrousos ^[4] ; Bram,Rochwerg ^[5] ; Amanda,Busby ^[6] ; Barbara,Ruaro ^[3] ; Bernd,Meibohm ^[7]

作者单位： Memphis Veterans Affairs Medical Center Research Service, Departments of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA. gmeduri@uthsc.edu.;Pulmonary, Critical Care, and Sleep Medicine Service and Research Service, Memphis Veterans Affairs Medical Center, 1030 Jefferson Avenue, Suite room #CW444, Memphis, TN, 38104, USA. gmeduri@uthsc.edu. ^[1] Department of Critical Care, Raymond Poincaré Hospital (AP-HP), Laboratory Infection and Inflammation, U1173, Faculty of Health Science Simone Veil, University of Versailles SQY, University Paris Saclay, INSERM, FHU SEPSIS, RHU RECORDS, Versailles, France. ^[2] Pulmonology Department, University Hospital of Cattinara, University of Trieste, Trieste, Italy. ^[3] University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece. ^[4] Department of Medicine, McMaster University, Hamilton, ON, Canada.;Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. ^[5] Health Research Methods Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK. ^[6] Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA. ^[7]

关键词 Acute respiratory distress syndrome Duration Glucocorticoid Glucocorticoid receptor Pharmacodynamic Randomized trial Receptor affinity

医学主题词糖皮质激素类(Glucocorticoids);人类(Humans);下丘脑-垂体系统(Hypothalamo-Hypophyseal System);甲泼尼龙(Methylprednisolone);垂体肾上腺系统(Pituitary-Adrenal System)

DOI 10.1007/s00134-020-06289-8

PMID 33150472

发布时间 2024-08-28

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