Brain pathology and cerebellar purkinje cell loss in a mouse model of chronic neuronopathic Gaucher disease.

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作者： Yael,Pewzner-Jung ^[1] ; Tammar,Joseph ^[2] ; Shani,Blumenreich ^[2] ; Ayelet,Vardi ^[2] ; Natalia Santos,Ferreira ^[2] ; Soo Min,Cho ^[2] ; Raya,Eilam ^[3] ; Michael,Tsoory ^[3] ; Inbal E,Biton ^[3] ; Vlad,Brumfeld ^[3] ; Rebecca,Haffner-Krausz ^[3] ; Ori,Brenner ^[3] ; Nir,Sharabi ^[3] ; Yoseph,Addadi ^[4] ; Tomer-Meir,Salame ^[4] ; Ron,Rotkopf ^[4] ; Noa,Wigoda ^[4] ; Nadav,Yayon ^[5] ; Alfred H,Merrill ^[6] ; Raphael,Schiffmann ^[7] ; Anthony H,Futerman ^[2]

作者单位： Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel. Electronic address: yael.pewzner-jung@weizmann.ac.il. ^[1] Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel. ^[2] Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel. ^[3] Life Science Core Facilities, Weizmann Institute of Science, Rehovot, Israel. ^[4] Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel. ^[5] School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. ^[6] Baylor Scott & White Research Institute, Dallas, TX, USA. ^[7]

关键词 Acid-beta glucosidase Cerebellum Gaucher disease (GD)Gba(-/-);Gba(tg) mice Neuropathology Parkinson's disease Purkinje neurons Sphingolipids