首页> Genomics> Comprehensive in silico mutational-sensitivity analysis of PTEN establishes signature regions implicated in pathogenesis of Autism Spectrum Disorders.

Comprehensive in silico mutational-sensitivity analysis of PTEN establishes signature regions implicated in pathogenesis of Autism Spectrum Disorders.

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第一作者： Ashitha,S Niranjana Murthy

第一单位： Genetics and Genomics Laboratory, Department of Studies in Genetics and Genomics, University of Mysore, Manasagangotri 570006, Karnataka, India. Electronic address: ashitha@zoology.uni-mysore.ac.in.

作者： Ashitha,S Niranjana Murthy ^[1] ; Raviraj,V Suresh ^[2] ; Ramachandra,Nallur B ^[3]

作者单位： Genetics and Genomics Laboratory, Department of Studies in Genetics and Genomics, University of Mysore, Manasagangotri 570006, Karnataka, India. Electronic address: ashitha@zoology.uni-mysore.ac.in. ^[1] Scientist-B, Central Sericultural Research and Training Institute, Central Silk Board, Berhampore, Murshidabad 742101, India. ^[2] Genetics and Genomics Laboratory, Department of Studies in Genetics and Genomics, University of Mysore, Manasagangotri 570006, Karnataka, India. Electronic address: nallurbr@gmail.com. ^[3]

关键词 Autism Spectrum Disorders (ASD)In silico Molecular dynamics, regulatory SNPs Mutational-hotspots PTEN Pathogenic variations Signature regions

医学主题词计算生物学(Computational Biology);保守序列(Conserved Sequence);基因调控网络(Gene Regulatory Networks);人类(Humans);突变(Mutation);PTEN磷酸水解酶(PTEN Phosphohydrolase);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1016/j.ygeno.2020.10.035

PMID 33152507

发布时间 2022-02-23

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