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首页> Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie> In vitro and in vivo antimicrobial activities of a novel piperazine-containing benzothiazinones candidate TZY-5-84 against Mycobacterium tuberculosis.

In vitro and in vivo antimicrobial activities of a novel piperazine-containing benzothiazinones candidate TZY-5-84 against Mycobacterium tuberculosis.

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作者： Shaochen,Guo ^[1] ; Lei,Fu ^[1] ; Bin,Wang ^[1] ; Xi,Chen ^[1] ; Jiaojie,Zhao ^[1] ; Mingliang,Liu ^[2] ; Yu,Lu ^[3]

作者单位： Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China. ^[1] Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: lmllyx@126.com. ^[2] Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China. Electronic address: luyu4876@hotmail.com. ^[3]

关键词 DprE1 inhibitor Mycobacterium tuberculosis anti-tuberculosis activity piperazine-containing benzothiazinone analogue

主题词动物(Animals);抗结核药(Antitubercular Agents);剂量效应关系, 药物(Dose-Response Relationship, Drug);女(雌)性(Female);巨噬细胞(Macrophages);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C3H(Mice, Inbred C3H);微生物敏感性试验(Microbial Sensitivity Tests);结核分枝杆菌(Mycobacterium tuberculosis);哌嗪类(Piperazines);噻嗪类(Thiazines);时间因素(Time Factors);结核(Tuberculosis);结核, 抗多种药物性(Tuberculosis, Multidrug-Resistant)

DOI 10.1016/j.biopha.2020.110777

PMID 33152936

发布时间 2021-02-19

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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