TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer.

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作者： Qiang,Tang ^[1] ; Jinhuang,Chen ^[2] ; Ziyang,Di ^[3] ; Wenzheng,Yuan ^[2] ; Zili,Zhou ^[3] ; Zhengyi,Liu ^[3] ; Shengbo,Han ^[3] ; Yanwei,Liu ^[3] ; Guoguang,Ying ^[2] ; Xiaogang,Shu ^[4] ; Maojun,Di ^[5]

作者单位： Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjins Clinical Research Center for Cancer, Tianjin, 300060, China. ^[1] Department of General Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China. ^[2] Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ^[3] Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjins Clinical Research Center for Cancer, Tianjin, 300060, China. yingguoguang163@163.com. ^[4] Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. sxg678@yahoo.com. ^[5] Department of General Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China. maojundi@126.com. ^[6]

关键词 Colorectal cancer EMT SOX2 Stemness TM4SF1 Wnt/β-catenin