Development and validation of a sensitive liquid chromatography tandem mass spectrometry assay for the simultaneous determination of ten kinase inhibitors in human serum and plasma.

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作者： Fatemeh,Aghai ^[1] ; Sebastian,Zimmermann ^[2] ; Max,Kurlbaum ^[3] ; Pius,Jung ^[4] ; Theo,Pelzer ^[5] ; Hartwig,Klinker ^[5] ; Nora,Isberner ^[1] ; Oliver,Scherf-Clavel ^[1]

作者单位： Department of Internal Medicine II, University of Würzburg Medical Center, Oberdürrbacher Str. 6, 97080, Würzburg, Germany. ^[1] Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany. ^[2] Department of Internal Medicine I, University of Würzburg Medical Center, Oberdürrbacher Str. 6, 97080, Würzburg, Germany. ^[3] Core Unit Clinical Mass Spectrometry, University of Würzburg Medical Center, Oberdürrbacher Str. 6, 97080, Würzburg, Germany. ^[4] Department of Internal Medicine I, Division of Pneumonology, University of Würzburg Medical Center, Oberdürrbacher Str. 6, 97080, Würzburg, Germany. ^[5] Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany. oliver.scherf-clavel@uni-wuerzburg.de. ^[6]

关键词 Afatinib Kinase inhibitors Liquid chromatography tandem mass spectrometry (LC-MS/MS)Osimertinib Therapeutic drug monitoring