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Mechanisms to reduce the cytotoxicity of pharmacological nicotinamide concentrations in the pathogenic fungus Candida albicans.

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第一作者： Rahul,Ghugari

第一单位： Institute for Research in Immunology and Cancer, Université de Montréal, QC, Canada.;Programme de Biologie Moléculaire, Université de Montréal, QC, Canada.

作者： Rahul,Ghugari ^[1] ; Sarah,Tsao ^[2] ; Mark,Schmidt ^[3] ; Éric,Bonneil ^[2] ; Charles,Brenner ^[4] ; Alain,Verreault ^[5]

作者单位： Institute for Research in Immunology and Cancer, Université de Montréal, QC, Canada.;Programme de Biologie Moléculaire, Université de Montréal, QC, Canada. ^[1] Institute for Research in Immunology and Cancer, Université de Montréal, QC, Canada. ^[2] Department of Biochemistry, Carver College of Medicine, University of Iowa, IA, USA. ^[3] Department of Diabetes & Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA. ^[4] Institute for Research in Immunology and Cancer, Université de Montréal, QC, Canada.;Département de Pathologie et Biologie Cellulaire, Université de Montréal, QC, Canada. ^[5]

关键词 Candida albicans H3K56 hyperacetylation NAM exchange reaction nicotinamide cytotoxicity pathogenic fungi pharmacological nicotinamide concentration sirtuin Hst3 sirtuin inhibition supraphysiological nicotinamide concentration vitamin B3