Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.-论文-万方医学网

作者： Naidu S,Chowdari ^[1] ; Yong,Zhang ^[2] ; Ivar,McDonald ^[3] ; Walter,Johnson ^[1] ; David R,Langley ^[3] ; Prasanna,Sivaprakasam ^[3] ; Robert,Mate ^[1] ; Tram,Huynh ^[2] ; Srikanth,Kotapati ^[1] ; Madhura,Deshpande ^[1] ; Chin,Pan ^[1] ; Daniel,Menezes ^[1] ; Yichong,Wang ^[1] ; Chetana,Rao ^[1] ; Ganapathy,Sarma ^[1] ; Bethanne M,Warrack ^[2] ; Vangipuram S,Rangan ^[1] ; Sung,Mei-Chen ^[1] ; Pina,Cardarelli ^[1] ; Shrikant,Deshpande ^[1] ; David,Passmore ^[1] ; Richard,Rampulla ^[2] ; Arvind,Mathur ^[2] ; Robert,Borzilleri ^[2] ; Arvind,Rajpal ^[1] ; Gregory,Vite ^[2] ; Sanjeev,Gangwar ^[1]

作者单位： Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States. ^[1] Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543, United States. ^[2] Bristol Myers Squibb Research & Early Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States. ^[3]

主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);苯二氮|艹卓|类(Benzodiazepines);细胞增殖(Cell Proliferation);药物设计(Drug Design);女(雌)性(Female);G(M1)神经节苷脂(G(M1) Ganglioside);GPI连接蛋白质类(GPI-Linked Proteins);人类(Humans);免疫轭合物(Immunoconjugates);肺肿瘤(Lung Neoplasms);小鼠(Mice);小鼠, SCID(Mice, SCID);小细胞肺癌(Small Cell Lung Carcinoma);胃肿瘤(Stomach Neoplasms);构效关系(Structure-Activity Relationship);四氢异喹啉类(Tetrahydroisoquinolines);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1021/acs.jmedchem.0c01385

PMID 33155811

发布时间 2021-12-04

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Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.

Journal of medicinal chemistry

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Journal of medicinal chemistry

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Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.

Journal of medicinal chemistry

相似文献

Journal of medicinal chemistry

相关期刊

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