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The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function.

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第一作者： Christopher,Mapperley

第一单位： Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.;Laboratory of Haematopoietic Stem Cell and Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.

作者： Christopher,Mapperley ^[1] ; Louie N,van de Lagemaat ^[1] ; Hannah,Lawson ^[2] ; Andrea,Tavosanis ^[2] ; Jasmin,Paris ^[1] ; Joana,Campos ^[2] ; David,Wotherspoon ^[2] ; Jozef,Durko ^[2] ; Annika,Sarapuu ^[2] ; Junho,Choe ^[3] ; Ivayla,Ivanova ^[4] ; Daniela S,Krause ^[5] ; Alex,von Kriegsheim ^[6] ; Christian,Much ^[4] ; Marcos,Morgan ^[4] ; Richard I,Gregory ^[3] ; Adam J,Mead ^[7] ; Dónal,O'Carroll ^[8] ; Kamil R,Kranc ^[1]

作者单位： Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.;Laboratory of Haematopoietic Stem Cell and Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK. ^[1] Laboratory of Haematopoietic Stem Cell and Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK. ^[2] Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA.;Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA. ^[3] Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.;Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK. ^[4] Georg-Speyer-Haus and Goethe University, Frankfurt, Germany. ^[5] Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, Edinburgh, UK. ^[6] Medical Research Council Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK. ^[7] Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.;Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.;Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK. ^[8]