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β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway.

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第一作者： Sourish,Ghosh

第一单位： Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

作者： Sourish,Ghosh ^[1] ; Teegan A,Dellibovi-Ragheb ^[1] ; Adeline,Kerviel ^[1] ; Eowyn,Pak ^[1] ; Qi,Qiu ^[1] ; Matthew,Fisher ^[1] ; Peter M,Takvorian ^[2] ; Christopher,Bleck ^[3] ; Victor W,Hsu ^[4] ; Anthony R,Fehr ^[5] ; Stanley,Perlman ^[5] ; Sooraj R,Achar ^[6] ; Marco R,Straus ^[7] ; Gary R,Whittaker ^[7] ; Cornelis A M,de Haan ^[8] ; John,Kehrl ^[9] ; Grégoire,Altan-Bonnet ^[10] ; Nihal,Altan-Bonnet ^[11]

作者单位： Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. ^[1] Federated Department of Biological Sciences, Rutgers-State University of New Jersey, Newark, NJ, USA. ^[2] Electron Microscopy Core Facility, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. ^[3] Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA. ^[4] Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA. ^[5] lmmunodynamics Group - Laboratory of Integrative Cancer Immunology, National Cancer Institute, Bethesda, MD, USA. ^[6] Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA. ^[7] Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. ^[8] B-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ^[9] lmmunodynamics Group - Laboratory of Integrative Cancer Immunology, National Cancer Institute, Bethesda, MD, USA. Electronic address: gregoire.altan-bonnet@nih.gov. ^[10] Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: nihal.altan-bonnet@nih.gov. ^[11]

关键词 CD1067700 Rab7 SARS-CoV-2 acidification/deacidification ARL8b antigen presentation coronavirus lysosome pH viral egress viral immunology