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Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines.

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第一作者： Wei,Zhao

第一单位： Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

作者： Wei,Zhao ^[1] ; Jun,Li ^[2] ; Mei-Ju M,Chen ^[2] ; Yikai,Luo ^[3] ; Zhenlin,Ju ^[2] ; Nicole K,Nesser ^[4] ; Katie,Johnson-Camacho ^[4] ; Christopher T,Boniface ^[4] ; Yancey,Lawrence ^[4] ; Nupur T,Pande ^[4] ; Michael A,Davies ^[5] ; Meenhard,Herlyn ^[6] ; Taru,Muranen ^[7] ; Ioannis K,Zervantonakis ^[8] ; Erika,von Euw ^[9] ; Andre,Schultz ^[2] ; Shwetha V,Kumar ^[2] ; Anil,Korkut ^[2] ; Paul T,Spellman ^[4] ; Rehan,Akbani ^[2] ; Dennis J,Slamon ^[9] ; Joe W,Gray ^[10] ; Joan S,Brugge ^[7] ; Yiling,Lu ^[11] ; Gordon B,Mills ^[12] ; Han,Liang ^[13]

作者单位： Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ^[1] Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ^[2] Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA. ^[3] Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97201, USA. ^[4] Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ^[5] Molecular and Cellular Oncogenesis Program, Wistar Institute, Philadelphia, PA 19104, USA. ^[6] Department of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA. ^[7] Department of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA; Department of Bioengineering, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15219, USA. ^[8] Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. ^[9] Center for Spatial Systems Biomedicine, Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97201, USA. ^[10] Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ^[11] Knight Cancer Institute and Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA. Electronic address: gmills@ohsu.org. ^[12] Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: hliang1@mdanderson.org. ^[13]

关键词 biomarker cancer signaling pathway drug response protein array

医学主题词抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);计算生物学(Computational Biology);抗药性, 肿瘤(Drug Resistance, Neoplasm);人类(Humans);分子靶向治疗(Molecular Targeted Therapy);肿瘤(Neoplasms);蛋白质阵列分析(Protein Array Analysis);蛋白质组学(Proteomics);用户计算机接口(User-Computer Interface)

DOI 10.1016/j.ccell.2020.10.008

PMID 33157050

发布时间 2021-12-15

基金项目

P30 CA016672/CA/NCI NIH HHS/United States P50 CA217685/CA/NCI NIH HHS/United States R00 CA222554/CA/NCI NIH HHS/United States P30 CA010815/CA/NCI NIH HHS/United States U54 HG008100/HG/NHGRI NIH HHS/United States R01 CA232256/CA/NCI NIH HHS/United States P50 CA221703/CA/NCI NIH HHS/United States U24 CA210949/CA/NCI NIH HHS/United States U24 CA143883/CA/NCI NIH HHS/United States U24 CA210950/CA/NCI NIH HHS/United States UL1 TR003167/TR/NCATS NIH HHS/United States P01 CA114046/CA/NCI NIH HHS/United States P50 CA098258/CA/NCI NIH HHS/United States U01 CA168394/CA/NCI NIH HHS/United States U01 CA217842/CA/NCI NIH HHS/United States U24 CA209851/CA/NCI NIH HHS/United States R50 CA221675/CA/NCI NIH HHS/United States

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