The master developmental regulator Jab1/Cops5/Csn5 is essential for proper bone growth and survival in mice.

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作者： William E,Samsa ^[1] ; Murali K,Mamidi ^[1] ; Bryan S,Hausman ^[2] ; Lindsay A,Bashur ^[2] ; Edward M,Greenfield ^[3] ; Guang,Zhou ^[4]

作者单位： Department of Orthopaedics, Case Western Reserve University, Cleveland, OH 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. ^[1] Department of Orthopaedics, Case Western Reserve University, Cleveland, OH 44106, USA. ^[2] Indiana University School of Medicine, Indianapolis, IN 46202, USA. ^[3] Department of Orthopaedics, Case Western Reserve University, Cleveland, OH 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: gxz27@case.edu. ^[4]

关键词 Bone microarchitecture COP9 signalosome Jab1/Csn5/Cops5 Osteoblast precursors TGFβ/BMP signaling

主题词动物(Animals);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);小鼠(Mice);骨生成(Osteogenesis);肽水解酶类(Peptide Hydrolases);X线显微体层摄影术(X-Ray Microtomography)

DOI 10.1016/j.bone.2020.115733

PMID 33157284

发布时间 2022-02-02

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