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首页> Toxicology> Novel pyridinium oximes enhance 24-h survivability against a lethal dose of nerve agent surrogate in adult female rats.

Novel pyridinium oximes enhance 24-h survivability against a lethal dose of nerve agent surrogate in adult female rats.

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作者： Jason M,Garcia ^[1] ; Edward C,Meek ^[2] ; Janice E,Chambers ^[3]

作者单位： Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, P.O. Box 6100, Mississippi State, MS, 39762, USA. Electronic address: jason.garcia.16@us.af.mil. ^[1] Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, P.O. Box 6100, Mississippi State, MS, 39762, USA. Electronic address: emeek@cvm.msstate.edu. ^[2] Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, P.O. Box 6100, Mississippi State, MS, 39762, USA. Electronic address: chambers@cvm.msstate.edu. ^[3]

关键词 Brain penetration Nerve agent surrogate Neuroprotection Nitrophenyl isopropyl methylphosphonate (NIMP)Oxime Seizure-like behavior cessation

主题词动物(Animals);解毒药(Antidotes);血脑屏障(Blood-Brain Barrier);脑(Brain);胆碱酯酶抑制剂(Cholinesterase Inhibitors);女(雌)性(Female);半数致死量(Lethal Dose 50);男(雄)性(Male);肟类(Oximes);解磷定化合物(Pralidoxime Compounds);吡啶鎓化合物(Pyridinium Compounds);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);沙林(Sarin);存活率(Survival Rate)

DOI 10.1016/j.tox.2020.152626

PMID 33159982

发布时间 2021-12-16

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