Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif.

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作者： Maria S,Eriksen ^[1] ; Oleksii,Nikolaienko ^[2] ; Erik I,Hallin ^[1] ; Sverre,Grødem ^[2] ; Helene J,Bustad ^[1] ; Marte I,Flydal ^[1] ; Ian,Merski ^[2] ; Tomohisa,Hosokawa ^[1] ; Daniela,Lascu ^[2] ; Shreeram,Akerkar ^[1] ; Jorge,Cuéllar ^[2] ; James J,Chambers ^[3] ; Rory,O'Connell ^[4] ; Gopinath,Muruganandam ^[1] ; Remy,Loris ^[2] ; Christine,Touma ^[1] ; Tambudzai,Kanhema ^[2] ; Yasunori,Hayashi ^[5] ; Margaret M,Stratton ^[6] ; José M,Valpuesta ^[3] ; Petri,Kursula ^[7] ; Aurora,Martinez ^[8] ; Clive R,Bramham ^[7]

作者单位： Department of Biomedicine, University of Bergen, Norway. ^[1] KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway. ^[2] Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, MA, USA. ^[3] Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan. ^[4] Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain. ^[5] Institute for Applied Life Sciences, University of Massachusetts Amherst, MA, USA. ^[6] VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, Brussels, Belgium. ^[7] Structural Biology Brussels, Department of Bioengineering Sciences, Vrije Universiteit Brussel, Belgium. ^[8] Faculty of Biochemistry and Molecular Biology & Biocenter Oulu, University of Oulu, Finland. ^[9]

关键词 activity-regulated cytoskeleton-associated protein (Arc)/coiled-coil interactions/protein oligomerization retrovirus-like capsid/synaptic plasticity