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A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin.

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第一作者： Morgan,Levine

第一单位： Department of Pathology, Yale University School of Medicine, New Haven, United States.;Program in Computational Biology and Bioinformatics, Yale University, New Haven, United States.

作者： Morgan,Levine ^[1] ; Ross A,McDevitt ^[2] ; Margarita,Meer ^[3] ; Kathy,Perdue ^[2] ; Andrea,Di Francesco ^[4] ; Theresa,Meade ^[2] ; Colin,Farrell ^[5] ; Kyra,Thrush ^[6] ; Meng,Wang ^[6] ; Christopher,Dunn ^[7] ; Matteo,Pellegrini ^[8] ; Rafael,de Cabo ^[9] ; Luigi,Ferrucci ^[9]

作者单位： Department of Pathology, Yale University School of Medicine, New Haven, United States.;Program in Computational Biology and Bioinformatics, Yale University, New Haven, United States. ^[1] Comparative Medicine Section, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, United States. ^[2] Department of Pathology, Yale University School of Medicine, New Haven, United States. ^[3] Translational Gerontology Branch, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, United States.;Calico Life Sciences, South San Francisco, United States. ^[4] Department of Human Genetics, University of California, Los Angeles, Los Angeles, United States. ^[5] Program in Computational Biology and Bioinformatics, Yale University, New Haven, United States. ^[6] Laboratory of Molecular Biology and Immunology, Flow Core Unit, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, United States. ^[7] Molecular Biology Institute and Departments of Energy Laboratory of Structural Biology and Molecular Medicine, and Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, United States. ^[8] Translational Gerontology Branch, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, United States. ^[9]

关键词 DNA methylation biological age caloric restriction computational biology epigenetic clock genetics genomics mouse rat systems biology