Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration.

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作者： Baohong,Luo ^[1] ; Yikang,Zhan ^[2] ; Minqi,Luo ^[3] ; Huimin,Dong ^[1] ; Jun,Liu ^[2] ; Yingtong,Lin ^[3] ; Junsong,Zhang ^[4] ; Guanwen,Wang ^[4] ; Els,Verhoeyen ^[1] ; Yiwen,Zhang ^[2] ; Hui,Zhang ^[3]

作者单位： Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China. ^[1] Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China. ^[2] Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China. ^[3] Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, Guangdong, China. ^[4] CIRI - International Center for Infectiology, Research team EVIR, Inserm, U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, University of Lyon, Lyon, France. ^[5] Université Côte d'Azur, INSERM, C3M, 06204, Nice, France. ^[6] Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China. zhangyw57@mail.sysu.edu.cn. ^[7] Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China. zhangyw57@mail.sysu.edu.cn. ^[8] Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China. zhangyw57@mail.sysu.edu.cn. ^[9] Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China. zhangh92@mail.sysu.edu.cn. ^[10] Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China. zhangh92@mail.sysu.edu.cn. ^[11] Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China. zhangh92@mail.sysu.edu.cn. ^[12]