首页> European journal of medicinal chemistry> Exploring the ability of dihydropyrimidine-5-carboxamide and 5-benzyl-2,4-diaminopyrimidine-based analogues for the selective inhibition of L. major dihydrofolate reductase.

Exploring the ability of dihydropyrimidine-5-carboxamide and 5-benzyl-2,4-diaminopyrimidine-based analogues for the selective inhibition of L. major dihydrofolate reductase.

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第一作者： Maria,Bibi

第一单位： Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060, Pakistan.

作者： Maria,Bibi ^[1] ; Naveeda Akhter,Qureshi ^[2] ; Abdul,Sadiq ^[3] ; Umar,Farooq ^[1] ; Abbas,Hassan ^[4] ; Nargis,Shaheen ^[2] ; Irfa,Asghar ^[5] ; Duaa,Umer ^[5] ; Azmat,Ullah ^[1] ; Farhan A,Khan ^[1] ; Muhammad,Salman ^[6] ; Ahtaram,Bibi ^[7] ; Umer,Rashid ^[8]

作者单位： Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060, Pakistan. ^[1] Department of Animal Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan. ^[2] Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, 18000, Dir (L), KP, Pakistan. ^[3] Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan. ^[4] Department of Biotechnology, COMSATS University Islamabad, Abbottabad Campus, 22060, Pakistan. ^[5] Department of Microbiology, National Institute of Health (NIH), Islamabad, 45320, Pakistan. ^[6] Department of Chemistry, Faculty of Physical Sciences, Kohat University of Science and Technology, 26000, Kohat, KP, Pakistan. ^[7] Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060, Pakistan. Electronic address: umerrashid@cuiatd.edu.pk. ^[8]

关键词 Antileishmanials Benzyl-2,4-diaminopyrimidines Dihydropyrimidine-5-carboxamides Human dihydrofolate reductase Leishmania major DHFR Methotrexate mimics