High Selectivity of an α-Conotoxin LvIA Analogue for α3β2 Nicotinic Acetylcholine Receptors Is Mediated by β2 Functionally Important Residues.

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作者： Xiaopeng,Zhu ^[1] ; Si,Pan ^[2] ; Manyu,Xu ^[3] ; Lu,Zhang ^[3] ; Jinfang,Yu ^[2] ; Jinpeng,Yu ^[3] ; Yong,Wu ^[1] ; Yingxu,Fan ^[1] ; Haonan,Li ^[4] ; Igor E,Kasheverov ^[2] ; Denis S,Kudryavtsev ^[5] ; Victor I,Tsetlin ^[6] ; Yi,Xue ^[5] ; Dongting,Zhangsun ^[5] ; Xinquan,Wang ^[7] ; Sulan,Luo ^[4]

作者单位： Medical School, Guangxi University, Nanning 530004, China. ^[1] Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China. ^[2] The Ministry of Education Key Laboratory of Protein Science, School of Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Collaborative Innovation Center for Biotherapy, Tsinghua University, Beijing 100084, China. ^[3] Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China. ^[4] Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street 16/10, Moscow 117997, Russia. ^[5] Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Trubetskaya Street 8, bld. 2, Moscow 119991, Russia. ^[6] PhysBio of MePhi, Kashirskoe Ave. 31, Moscow 115409, Russia. ^[7]