Targeting the Allosteric Pathway That Interconnects the Core-Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl-2.
第一作者:
Ziqian,Wang
第一单位:
State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China.
作者:
主题词
别构调节(Allosteric Regulation);氨基酸序列(Amino Acid Sequence);药物释放系统(Drug Delivery Systems);HL-60细胞(HL-60 Cells);人类(Humans);肽碎片(Peptide Fragments);磷酰化(Phosphorylation);蛋白质结构, 二级(Protein Structure, Secondary);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);信号传导(Signal Transduction)
DOI
10.1021/acs.jmedchem.0c01290
PMID
33197310
发布时间
2020-12-31
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Journal of medicinal chemistry
13733-13744页
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