Maternal obesity persistently alters cardiac progenitor gene expression and programs adult-onset heart disease susceptibility.

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作者： Abdalla,Ahmed ^[1] ; Minggao,Liang ^[2] ; Lijun,Chi ^[3] ; Yu-Qing,Zhou ^[4] ; John G,Sled ^[5] ; Michael D,Wilson ^[2] ; Paul,Delgado-Olguín ^[6]

作者单位： Translational Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. ^[1] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; Genetics & Genome Biology, Hospital for Sick Children, Toronto, Ontario, M5G 0A4, Canada. ^[2] Translational Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 0A4, Canada. ^[3] Mouse Imaging Center, Hospital for Sick Children, Toronto, Ontario, M5T 3H7, Canada. ^[4] Mouse Imaging Center, Hospital for Sick Children, Toronto, Ontario, M5T 3H7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 1L7, Canada. ^[5] Translational Medicine, Hospital for Sick Children, Toronto, Ontario, M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; Heart & Stroke Richard Lewar Center of Excellence, Toronto, Ontario, M5S 3H2, Canada. Electronic address: paul.delgadoolguin@sickkids.ca. ^[6]

关键词 Cardiac progenitors Fetal programming of heart disease Gene expression Heart disease susceptibility Maternal obesity Myocardial remodeling Nkx2-5

主题词动物(Animals);体重(Body Weight);疾病易感性(Disease Susceptibility);女(雌)性(Female);基因表达(Gene Expression);基因表达调控(Gene Expression Regulation);心脏病(Heart Diseases);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 肥胖(Mice, Obese);心肌(Myocardium);NF-κB(NF-kappa B);肥胖症(Obesity);妊娠(Pregnancy);产前暴露迟发效应(Prenatal Exposure Delayed Effects)

DOI 10.1016/j.molmet.2020.101116

PMID 33212270

发布时间 2021-08-30

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Molecular metabolism

2021年43卷

101116页

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Maternal obesity persistently alters cardiac progenitor gene expression and programs adult-onset heart disease susceptibility.

Molecular metabolism

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Maternal obesity persistently alters cardiac progenitor gene expression and programs adult-onset heart disease susceptibility.

Molecular metabolism

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Molecular metabolism

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