Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers.

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第一作者： Ryan P,Kreiser

第一单位： Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996, USA.

作者： Ryan P,Kreiser ^[1] ; Aidan K,Wright ^[1] ; Natalie R,Block ^[1] ; Jared E,Hollows ^[1] ; Lam T,Nguyen ^[1] ; Kathleen,LeForte ^[1] ; Benedetta,Mannini ^[2] ; Michele,Vendruscolo ^[2] ; Ryan,Limbocker ^[1]

作者单位： Department of Chemistry and Life Science, United States Military Academy, West Point, NY 10996, USA. ^[1] Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. ^[2]

关键词 Alzheimer’s disease Parkinson’s disease countermeasures kinetics membrane protection misfolded protein oligomers protein homeostasis structure–toxicity relationships

主题词动物(Animals);人类(Humans);蛋白质多聚化(Protein Multimerization);蛋白平衡缺陷(Proteostasis Deficiencies)

DOI 10.3390/ijms21228651

PMID 33212787

发布时间 2021-03-03

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