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首页> Bioorganic chemistry> Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer.

Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer.

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作者： Liang,Zeng ^[1] ; Qiong,Wu ^[2] ; Teng,Wang ^[3] ; Li-Ping,Li ^[1] ; Xuanhao,Zhao ^[3] ; Kai,Chen ^[1] ; Jiayi,Qian ^[3] ; Li,Yuan ^[1] ; Hui,Xu ^[1] ; Wen-Jie,Mei ^[4]

作者单位： Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China. ^[1] The School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Province Engineering Centre for Molecular Probe & Biomedicine Imaging, Guangzhou 510006, China. ^[2] The School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. ^[3] The School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Province Engineering Centre for Molecular Probe & Biomedicine Imaging, Guangzhou 510006, China. Electronic address: wenjiemei@gdpu.edu.cn. ^[4]

关键词 DNA damage G-quadruplex DNA Intermolecular interaction Molecular docking Tanshinone IIA derivatives

主题词血管生成抑制剂(Angiogenesis Inhibitors);动物(Animals);抗肿瘤药(Antineoplastic Agents);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);DNA(DNA);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);G四链体(G-Quadruplexes);人类(Humans);咪唑类(Imidazoles);分子动力学模拟(Molecular Dynamics Simulation);分子结构(Molecular Structure);肿瘤转移(Neoplasm Metastasis);启动区, 遗传(Promoter Regions, Genetic);构效关系(Structure-Activity Relationship);斑马鱼(Zebrafish)

DOI 10.1016/j.bioorg.2020.104433

PMID 33213893

发布时间 2021-09-03

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Bioorganic chemistry

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