Mechanisms of a Sustained Anti-inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling.

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作者： Elin,Nyman ^[1] ; Maria,Lindh ^[2] ; William,Lövfors ^[1] ; Christian,Simonsson ^[3] ; Alexander,Persson ^[1] ; Daniel,Eklund ^[4] ; Erica,Bäckström ^[4] ; Markus,Fridén ^[2] ; Gunnar,Cedersund ^[2]

作者单位： Department of Biomedical Engineering, Linköping University, Linköping, Sweden. ^[1] Drug Metabolism and Pharmacokinetics, Early Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. ^[2] Department of Mathematics, Linköping University, Linköping, Sweden. ^[3] School of Medical Sciences, Faculty of Medicine and Health, Inflammatory Response and Infections Susceptibility Centre, Örebro University, Örebro, Sweden. ^[4] Translational PKPD Group, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. ^[5] Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden. ^[6]

主题词动物(Animals);消炎药(Anti-Inflammatory Agents);地塞米松(Dexamethasone);炎症(Inflammation);巨噬细胞, 肺泡(Macrophages, Alveolar);模型, 生物学(Models, Biological);大鼠(Rats)

DOI 10.1002/psp4.12568

PMID 33217190

发布时间 2021-01-11

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CPT: pharmacometrics & systems pharmacology

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2020年9卷12期

707-717页

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Mechanisms of a Sustained Anti-inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling.

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Mechanisms of a Sustained Anti-inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling.

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