Pre-depletion of TRBC1+ T cells promotes the therapeutic efficacy of anti-TRBC1 CAR-T for T-cell malignancies.
第一作者:
Chaoting,Zhang
第一单位:
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
作者:
主题词
动物(Animals);细胞凋亡(Apoptosis);细胞增殖(Cell Proliferation);细胞毒性, 免疫(Cytotoxicity, Immunologic);人类(Humans);免疫疗法, 过继(Immunotherapy, Adoptive);白血病, T细胞(Leukemia, T-Cell);淋巴细胞去除术(Lymphocyte Depletion);小鼠(Mice);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, SCID(Mice, SCID);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);T淋巴细胞(T-Lymphocytes);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1186/s12943-020-01282-7
PMID
33218364
发布时间
2021-08-03
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