Pre-depletion of TRBC1+ T cells promotes the therapeutic efficacy of anti-TRBC1 CAR-T for T-cell malignancies.

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第一作者： Chaoting,Zhang

第一单位： Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, 100142, China.

作者： Chaoting,Zhang ^[1] ; Heyilimu,Palashati ^[1] ; Zhuona,Rong ^[1] ; Ningjing,Lin ^[2] ; Luyan,Shen ^[1] ; Ying,Liu ^[3] ; Shance,Li ^[1] ; Bentong,Yu ^[4] ; Wenjun,Yang ^[5] ; Zheming,Lu ^[6]

作者单位： Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, 100142, China. ^[1] Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, 100142, China. ^[2] Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Genetics, Peking University Cancer Hospital & Institute, Beijing, 100142, China. ^[3] Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, 100142, China. yubentong@126.com. ^[4] Department of Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Jiangxi, 330006, China. yubentong@126.com. ^[5] Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, 100142, China. ywj007@yeah.net. ^[6] Key Laboratory of Fertility Preservation and Maintenance, School of Basic Medicine and the General Hospital, Ningxia Medical University, Yinchuan, 750004, Ningxia, China. ywj007@yeah.net. ^[7] Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, 100142, China. luzheming@bjmu.edu.cn. ^[8]

关键词 CAR-T T cell receptor β-chain constant region 1 T-cell malignancy