首页> ALTEX> Predicting human tissue exposures to xenobiotics using a bottom-up physiologically-based biokinetic model

Predicting human tissue exposures to xenobiotics using a bottom-up physiologically-based biokinetic model

导出 LinkOut

翻译打印收藏纠错

第一作者： Shawn P F,Tan

第一单位： Skin Research Institute of Singapore, Agency for Science Technology and Research, Singapore.;Innovations in Food and Chemical Safety, Agency for Science Technology and Research, Singapore.

作者： Shawn P F,Tan ^[1] ; Eric C Y,Chan ^[2] ; James C Y,Chan ^[3]

作者单位： Skin Research Institute of Singapore, Agency for Science Technology and Research, Singapore.;Innovations in Food and Chemical Safety, Agency for Science Technology and Research, Singapore. ^[1] Innovations in Food and Chemical Safety, Agency for Science Technology and Research, Singapore.;Department of Pharmacy, National University of Singapore, Singapore. ^[2] Skin Research Institute of Singapore, Agency for Science Technology and Research, Singapore.;Innovations in Food and Chemical Safety, Agency for Science Technology and Research, Singapore.;Singapore Institute of Food and Biotechnology Innovation, Agency for Science, Technology and Research, Singapore. ^[3]

关键词 mechanistic scaling physiologically-based biokinetic modeling tissue concentrations transporters In vitro-to-in vivo extrapolation

主题词动物(Animals);药物相互作用(Drug Interactions);人类(Humans);肝(Liver);模型, 生物学(Models, Biological);异生物质(Xenobiotics)

DOI 10.14573/altex.2007151

PMID 33219385

发布时间 2021-10-28

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交