首页> Clinical epigenetics> Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular programming.

Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular programming.

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第一作者： Karen L,Leung

第一单位： Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.

作者： Karen L,Leung ^[1] ; Smriti,Sanchita ^[1] ; Catherine T,Pham ^[1] ; Brett A,Davis ^[2] ; Mariam,Okhovat ^[2] ; Xiangming,Ding ^[3] ; Phillip,Dumesic ^[4] ; Tristan R,Grogan ^[5] ; Kevin J,Williams ^[6] ; Marco,Morselli ^[7] ; Feiyang,Ma ^[7] ; Lucia,Carbone ^[8] ; Xinmin,Li ^[3] ; Matteo,Pellegrini ^[7] ; Daniel A,Dumesic ^[1] ; Gregorio D,Chazenbalk ^[9]

作者单位： Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. ^[1] Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Sciences University, Portland, OR, 97239, USA. ^[2] Technology Center for Genomics and Bioinformatics, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. ^[3] Dana-Farber Cancer Institute, Boston, MA, 02115, USA. ^[4] Department of Medicine Statistics Core, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. ^[5] UCLA Lipidomics Lab, Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA, 90095, USA. ^[6] Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA, 90095, USA. ^[7] Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Sciences University, Portland, OR, 97239, USA.;Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR, 97239, USA.;Department of Medical Information and Clinical Epidemiology, Oregon Health and Sciences University, Portland, OR, 97239, USA.;Division of Genetics, Oregon National Primate Research Center, Beaverton, OR, 97006, USA. ^[8] Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. gchazenbalk@mednet.ucla.edu. ^[9]

关键词 Adipogenesis Adipose stem cells Cellular programming Chromatin accessibility De novo synthesis of fatty acids Fat storage Gene expression Polycystic ovary syndrome Total content Transcriptional factors