A self-activating nanovesicle with oxygen-depleting capability for efficient hypoxia-responsive chemo-thermo cancer therapy.

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第一作者： Shi-Xiong,Chen

第一单位： State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China.

作者： Shi-Xiong,Chen ^[1] ; Fengfeng,Xue ^[2] ; Yichen,Kuang ^[1] ; Siyu,Chen ^[3] ; Danli,Sheng ^[4] ; Hangrong,Chen ^[5]

作者单位： State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China. ^[1] State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China. Electronic address: xuefengfeng@mail.sic.ac.cn. ^[2] Department of Medical Imaging, The Third Affiliated Hospital, Orthopedic Hospital of Guangdong Province, Southern Medical University, Guangdong, 510000, PR China. ^[3] Department of Ultrasound, Fudan University, Shanghai Cancer Center, Shanghai, 200032, PR China. ^[4] State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, PR China. Electronic address: hrchen@mail.sic.ac.cn. ^[5]

关键词 Activatable thermotherapy Endogenous compound Hypoxia-based chemotherapy Oxygen-depleting capability Self-activating nanovesicle

主题词细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);过氧化氢(Hydrogen Peroxide);纳米粒子(Nanoparticles);肿瘤(Neoplasms);氧(Oxygen);药物前体(Prodrugs)

DOI 10.1016/j.biomaterials.2020.120533

PMID 33228991

发布时间 2021-05-24

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