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首页> Blood> Platelet extracellular vesicles mediate transfusion-related acute lung injury by imbalancing the sphingolipid rheostat.

Platelet extracellular vesicles mediate transfusion-related acute lung injury by imbalancing the sphingolipid rheostat.

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作者： Mark J,McVey ^[1] ; Sarah,Weidenfeld ^[2] ; Mazharul,Maishan ^[3] ; Chris,Spring ^[4] ; Michael,Kim ^[5] ; Arata,Tabuchi ^[6] ; Victoria,Srbely ^[1] ; Alisa,Takabe-French ^[1] ; Szandor,Simmons ^[1] ; Christoph,Arenz ^[1] ; John W,Semple ^[1] ; Wolfgang M,Kuebler ^[1]

作者单位： Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, ON, Canada. ^[1] Department of Anesthesiology and Pain Medicine, and. ^[2] Department of Physiology, University of Toronto, Toronto, ON, Canada. ^[3] Department of Anesthesia and Pain Medicine, The Hospital for Sick Children (SickKids), Toronto, ON, Canada. ^[4] Department of Physics, Ryerson University, Toronto, ON, Canada. ^[5] Institute of Physiology, Charité-Universitätsmedizin, Berlin, Germany. ^[6] Institute for Chemistry, Humboldt University, Berlin, Germany. ^[7] Department of Pharmacology. ^[8] Department of Medicine, and. ^[9] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. ^[10] Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden; and. ^[11] Department of Surgery, University of Toronto, Toronto, ON, Canada. ^[12]

主题词动物(Animals);血小板(Blood Platelets);血液保存(Blood Preservation);神经酰胺类(Ceramides);内皮细胞(Endothelial Cells);内毒素类(Endotoxins);人类(Humans);溶血磷脂素类(Lysophospholipids);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);模型, 生物学(Models, Biological);血小板输注(Platelet Transfusion);鞘脂类(Sphingolipids);鞘磷脂磷酸二酯酶(Sphingomyelin Phosphodiesterase);鞘氨醇(Sphingosine)

DOI 10.1182/blood.2020005985

PMID 33232973

发布时间 2021-05-21

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Blood

Blood

2021年137卷5期

690-701页

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