首页> Molecular cancer> circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway.

circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway.

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第一作者： Wei,Gao

第一单位： Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.;Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.;Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.;Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, 030001, China.;Department of Cell Biology and Genetics, Basic Medical School of Shanxi Medical University, Taiyuan, 030001, China.

作者： Wei,Gao ^[1] ; Huina,Guo ^[2] ; Min,Niu ^[2] ; Xiwang,Zheng ^[2] ; Yuliang,Zhang ^[2] ; Xuting,Xue ^[2] ; Yunfeng,Bo ^[3] ; Xiaoya,Guan ^[2] ; Zhongxun,Li ^[2] ; Yujia,Guo ^[2] ; Long,He ^[2] ; Yu,Zhang ^[4] ; Li,Li ^[5] ; Jimin,Cao ^[4] ; Yongyan,Wu ^[6]

作者单位： Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.;Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.;Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.;Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, 030001, China.;Department of Cell Biology and Genetics, Basic Medical School of Shanxi Medical University, Taiyuan, 030001, China. ^[1] Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.;Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. ^[2] Department of Pathology, Shanxi Cancer Hospital, Shanxi Medical University, Taiyuan, 030013, China. ^[3] Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, 030001, China.;Department of Physiology, Shanxi Medical University, Taiyuan, 030001, China. ^[4] Department of Cell Biology and Genetics, Basic Medical School of Shanxi Medical University, Taiyuan, 030001, China. ^[5] Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. wuyongyan@sxent.org.;Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. wuyongyan@sxent.org.;Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. wuyongyan@sxent.org.;Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, 030001, China. wuyongyan@sxent.org.;Department of Biochemistry & Molecular Biology, Shanxi Medical University, Taiyuan, 030001, China. wuyongyan@sxent.org. ^[6]

关键词 Autophagy Chemoresistance Circular RNA Migration and invasion PI3K-Akt-mTOR signaling pathway PRKCI