Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms.

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作者： Bing-Rui,Zhou ^[1] ; Hanqiao,Feng ^[1] ; Seyit,Kale ^[2] ; Tara,Fox ^[3] ; Htet,Khant ^[3] ; Natalia,de Val ^[3] ; Rodolfo,Ghirlando ^[4] ; Anna R,Panchenko ^[5] ; Yawen,Bai ^[6]

作者单位： Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. ^[1] Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Balcova, Izmir 35330, Turkey. ^[2] Center of Macromolecular Microscopy, National Cancer Institute, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA. ^[3] Laboratory of Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ^[4] Department of Pathology and Molecular Medicine, School of Medicine, Queen's University, Kingston, ON K7L 3N6, Canada. ^[5] Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: baiyaw@mail.nih.gov. ^[6]

关键词 Cryo-EM NMR chromatin structure chromatosome chromatosome dynamics chromatosome structure linker histone isoform linker histone tail nucleosome single-chain antibody

主题词冷冻电子显微镜检查(Cryoelectron Microscopy);DNA(DNA);组蛋白类(Histones);人类(Humans);核小体(Nucleosomes);蛋白质亚型(Protein Isoforms)

DOI 10.1016/j.molcel.2020.10.038

PMID 33238161

发布时间 2023-09-19

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