Development of a bioanalytical method for an antisense therapeutic using high-resolution mass spectrometry.

导出 LinkOut

翻译打印收藏纠错

作者： Yuchen,Sun ^[1] ; Shin-Ichiro,Nitta ^[2] ; Kosuke,Saito ^[1] ; Ryuta,Hosogai ^[2] ; Keiko,Nakai ^[2] ; Ryoya,Goda ^[3] ; Masaaki,Kakehi ^[4] ; Kazuyuki,Murata ^[5] ; Takeru,Yamaguchi ^[5] ; Takeshi,Okuzono ^[6] ; Shinichi,Yamane ^[6] ; Yoshimasa,Enoki ^[7] ; Mitsuhiko,Kawabata ^[7] ; Kentaro,Takahara ^[8] ; Shimpei,Sato ^[9] ; Tokuyuki,Yoshida ^[10] ; Takao,Inoue ^[10] ; Yoshiro,Saito ^[1]

作者单位： Division of Medicinal Safety Science, National Institute of Health Sciences, Kanagawa, Japan. ^[1] LSI Medience Corporation, Tokyo, Japan. ^[2] Daiichi Sankyo Company, Limited, Tokyo, Japan. ^[3] Takeda Pharmaceutical Company, Limited, Tokyo, Japan. ^[4] Sumika Chemical Analysis Service, Ltd., Osaka, Japan. ^[5] Sekisui Medical Co., Ltd., Tokyo, Japan. ^[6] Shin Nippon Biomedical Laboratories, Ltd., Tokyo, Japan. ^[7] Thermo Fisher Scientific K.K., Tokyo, Japan. ^[8] Shimadzu GLC Ltd., Tokyo, Japan. ^[9] Division of Molecular Target & Gene Therapy Products, National Institute of Health Sciences, Kanagawa, Japan. ^[10]

关键词 antisense oligonucleotide clarity OTX high-resolution mass spectrometry ion-pairing reagent liquid chromatography

主题词生物疗法(Biological Therapy);校准(Calibration);色谱法, 液相(Chromatography, Liquid);DNA, 反义(DNA, Antisense);人类(Humans);质谱分析法(Mass Spectrometry);寡核苷酸类(Oligonucleotides)

DOI 10.4155/bio-2020-0225

PMID 33242248

发布时间 2021-08-10

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交